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Numera

Numera
Written by: Andreas Riklin / 4 min read
VIRTUAL TOUR OF THE DIGITIZED BIOPROCESSING LABORATORY AT THE ZHAW
February 22, 2024

Securecell AG and the Zurich University of Applied Sciences (ZHAW) have successfully completed a joint research collaboration project supported by Innosuisse - the Swiss Agency for Innovation Promotion.

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Numera
Written by: Pascal Vonlanthen / 6 min read
ADVANCED REAL-TIME MONITORING IN A CONTINUOUS BIOPROCESS
March 21, 2023

Automated sampling with Numera® as a central hub along a continuous bioprocess, enabling advanced real-time monitoring and process wide-control.

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Numera
Written by: Pascal Vonlanthen / 8 min read
FACILITATED AND RELIABLE PROCESS MONITORING DURING VACCINE PROCESS DEVELOPMENT AND PRODUCTION USING THE AUTOMATED SAMPLING SYSTEM NUMERA®
October 26, 2022

Vaccines are one of the most effective, cost-efficient, and sustainable ways of controlling infectious diseases and have had a significant impact on public health and longevity as well as intensive livestock production.

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Numera
Written by: Pascal Vonlanthen / 9 min read
AUTOMATED ON-LINE CELL CULTURE MONITORING USING NUMERA® AND THE CEDEX® HIRES ANALYZER
May 4, 2022

Every biopharmaceutical process aims for real-time monitoring and control of critical process parameters to minimize process variability and at the same time ensure predefined product quality.

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Numera
Written by: Andreas Riklin / 2 min read
NUMERA® ENABLES ON-LINE MD-LC-MS PEPTIDE MAPPING TO MONITOR MULTIPLE POST-TRANSLATIONAL PROTEIN MODIFICATIONS
April 15, 2022

A recently published article in the Journal of Chromatography A (Volume 1672, 7 June 2022, 463067; available online from April 15, 2022) shows that on-line monitoring of quality attributes (QAs) directly within the bioreactor can provide ...

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Numera
Written by: Sandro Waldmeier / 1 min read
COMPARISON OF NONINVASIVE, IN-SITU AND EXTERNAL MONITORING OF MICROBIAL GROWTH IN FED-BATCH CULTIVATIONS IN CORYNEBACTERIUM GLUTAMICUM
March 31, 2021

Automated bioprocess systems rely on accurate online measurements of cellular growth. In the present study, six sensors representing five different technologies, namely near-infrared absorbance, ....

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Lucullus Numera
Written by: Michele Bomio / 1 min read
BIOPROCESSING 4.0 DEMANDS (AND REWARDS) FINE-TUNED COORDINATION
March 2, 2021

Bioprocessing 4.0 is all about digitalization and how it can streamline the analysis and multidirectional communication of data—be it between equipment, among unit operations, or across groups and stages of development.

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Lucullus Numera
Written by: Virginia Mello / 0 min read
NEXT GENERATION MEAT
December 2, 2020

The world population is expected to reach 9.6 billion people by 2050, the middle class is growing, and meat consumption is expected to increase by 70%. Meat production requires a great amount of resources: 34 kgs of feed are necessary to produce 1 kg of meat, the same kg of meat requires ca..

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Lucullus Numera
Written by: Virginia Mello / 1 min read
PAT SOLUTIONS FOR THE FUTURE OF BIOPROCESSING 4.0
November 26, 2020

Pharmaceuticals have a prominent role in healthcare and their manufacturing requires innovative tools, scientific and engineering knowledge, and must at the same time comply with strict regulations.

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Lucullus Numera
Written by: Pascal Vonlanthen / 0 min read
EMPOWERING BIOPHARMA FOR FULL BIOPROCESS DEVELOPMENT AUTOMATION
August 19, 2020

Securecell offers a complete automated 24/7 device for sampling and sample processing to “close the loop” between analytics and process units. Discover in this GEN tech article how Numera® can dramatically implement productivity in biopharma process development.

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Lucullus Numera
Written by: Virginia Mello / 1 min read
THE HIGH-TECH SECRET BEHIND THE TRADITIONAL CHEESE SWISSNESS
July 2, 2020

Cheese is Switzerland’s most important agricultural-export product: around 170’000 tons of cheese are produced per year (40% of the total Swiss milk amount) with a value of around CHF 600 million. Agroscope, a federal research institute in Liebefeld, near Bern, Switzerland ....

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Numera
Written by: Paul Kroll / 0 min read
BIOPROCESS SAMPLING: A NECESSARY EVIL OR A CHANCE FOR IMPROVED MONITORING AND CONTROL?
October 9, 2019

Monitoring and control of critical process parameters (CPPs) in various bioprocesses is a prerequisite to gain a safe product and hence, is a major topic in Process Analytical Technology (PAT).

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Numera
Written by: Paul Kroll / 1 min read
A RELIABLE AUTOMATED SAMPLING SYSTEM FOR ON-LINE AND REAL-TIME MONITORING OF CHO CULTURES
October 9, 2019

Timely monitoring and control of critical process parameters and product attributes are still the basic tasks in bioprocess development. The current trend of automation and digitization in bioprocess technology targets ...

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Numera
Written by: Paul Kroll / 0 min read
SIMPLY GOOD MONITORING
September 10, 2019

Digitising process development can reduce the time delay between sampling and availability, and can increase the quality of the data obtained.

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Lucullus Numera
Written by: Alexandra Hofer / 0 min read
ON-LINE HPLC ANALYSIS AND DATA INTEGRATION WITH NUMERA AND LUCULLUS PIMS SHOWN ON THE EXAMPLE OF A CHO PROCESS
April 9, 2019

HPLC is the common reference method for product and metabolite analysis in bio-processes. Sampling is needed for these analyses, resulting in off-line measure-ments along the process.

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Lucullus Numera
Written by: Alexandra Hofer / 0 min read
NUMERA & LUCULLUS – AN INTEGRATED PAT SOLUTION COMBINING AUTOMATED SAMPLING AND PROCESS CONTROL
April 9, 2019

This application note presents two unique PAT tools, which can be used separately or together as an integrated PAT solution. The Numera system enables automated sampling, sample preparation, ...

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Lucullus Numera
Written by: Alexandra Hofer / 0 min read
GLUCOSE MONITORING AND CONTROL USING NUMERA, LUCULLUS PIMS AND CEDEX® BIO HT ANALYZER
April 9, 2019

Critical process parameters (CPPs) such as glucose must be monitored and con-trolled in every bioprocess in order to reach the desired product quality in the most efficient way.

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Numera
Written by: Alexandra Hofer / 0 min read
AUTOMATED BIOREACTOR SAMPLING FOR ON-LINE ANALYSIS OF AMINO ACIDS USING TWO APPROACHES: HPLC AND CEDEX® BIO HT ANALYZER
April 9, 2019

To facilitate optimal process control limiting substrates must be identified, monitored and controlled. Amino acids are often critical substances, especially in mammalian processes.

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