Automated sampling with Numera® as a central hub along a continuous bioprocess, enabling advanced real-time monitoring and process wide-control.
Vaccines are one of the most effective, cost-efficient, and sustainable ways of controlling infectious diseases and have had a significant impact on public health and longevity as well as intensive livestock production.
Every biopharmaceutical process aims for real-time monitoring and control of critical process parameters to minimize process variability and at the same time ensure predefined product quality.
A recently published article in the Journal of Chromatography A (Volume 1672, 7 June 2022, 463067; available online from April 15, 2022) shows that on-line monitoring of quality attributes (QAs) directly within the bioreactor can provide ...
Automated bioprocess systems rely on accurate online measurements of cellular growth. In the present study, six sensors representing five different technologies, namely near-infrared absorbance, ....
Bioprocessing 4.0 is all about digitalization and how it can streamline the analysis and multidirectional communication of data—be it between equipment, among unit operations, or across groups and stages of development.
The world population is expected to reach 9.6 billion people by 2050, the middle class is growing, and meat consumption is expected to increase by 70%. Meat production requires a great amount of resources: 34 kgs of feed are necessary to produce 1 kg of meat, the same kg of meat requires ca..
Pharmaceuticals have a prominent role in healthcare and their manufacturing requires innovative tools, scientific and engineering knowledge, and must at the same time comply with strict regulations.
Securecell offers a complete automated 24/7 device for sampling and sample processing to “close the loop” between analytics and process units. Discover in this GEN tech article how Numera® can dramatically implement productivity in biopharma process development.
Cheese is Switzerland’s most important agricultural-export product: around 170’000 tons of cheese are produced per year (40% of the total Swiss milk amount) with a value of around CHF 600 million. Agroscope, a federal research institute in Liebefeld, near Bern, Switzerland ....
Monitoring and control of critical process parameters (CPPs) in various bioprocesses is a prerequisite to gain a safe product and hence, is a major topic in Process Analytical Technology (PAT).
Timely monitoring and control of critical process parameters and product attributes are still the basic tasks in bioprocess development. The current trend of automation and digitization in bioprocess technology targets ...
Digitising process development can reduce the time delay between sampling and availability, and can increase the quality of the data obtained.
HPLC is the common reference method for product and metabolite analysis in bio-processes. Sampling is needed for these analyses, resulting in off-line measure-ments along the process.
This application note presents two unique PAT tools, which can be used separately or together as an integrated PAT solution. The Numera system enables automated sampling, sample preparation, ...
Critical process parameters (CPPs) such as glucose must be monitored and con-trolled in every bioprocess in order to reach the desired product quality in the most efficient way.
To facilitate optimal process control limiting substrates must be identified, monitored and controlled. Amino acids are often critical substances, especially in mammalian processes.
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