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    NEXT WEBINAR: DIGITAL BIOREACTORS FOR FAST AND PREDICTABLE SCALING OF SHEAR-SENSITIVE CELL CULTURES

    Written by: Mohi Ahmadinia

    Introduction

    Can you find the right operating conditions for your shear-sensitive cell culture before performing costly experiments?

    In this webinar, we explore how Digital Bioreactors can enable faster and more predictable scale-up. The underlying technology uses advanced CFD simulations, providing a first-principles basis for predicting bioreactor performance. However, building a reliable Digital Bioreactor requires experimental validation. We will show how a range of experiments supported the development of a Digital Bioreactor of a 250 mL stirred-tank bioreactor. These included microcarrier suspension experiments, 4D particle tracking velocimetry (4D-PTV), and automated kLa measurements using Lucullus.

    Once validated, the Digital Bioreactor serves as a virtual testbed that predicts how operating conditions affect suspension, mass transfer, and hydrodynamic stress. Rather than relying solely on trial-and-error experiments, we can screen operating conditions in-silico and identify promising experimental conditions, reducing the number of costly experiments needed during process development. Our principles can be applied to larger scales, supporting faster scale-up towards (clinical trial) production volumes. To demonstrate its practical value, we will show how the Digital Bioreactor guided the selection of operating conditions for iPSC-derived embryoid body formation, a process being developed for cRBC production.

     

    This webinar meets twice; please join at a time that works for you.
    Tue, December 8, 2026, 09:00 - 10:00 AM CET
    Tue, December 8, 2026, 05:00 - 06:00 PM CET
    Format: Online webinar
    Participation: Free of charge

    Duration: 50 min (content) + 10 min (Q&A)

     

    What You Will Learn

    During the webinar, Ramon will discuss:

    • Why conventional scale-up criteria fall short for shear-sensitive cultures
    • How a Digital Bioreactor is built and validated experimentally
    • How in-silico screening helps find optimal operating conditions across scales

      Scaling up bioreactors for shear-sensitive cell cultures is time-consuming and costly. As bioreactor volume increases, achieving sufficient mixing and mass transfer without exceeding shear stress limits becomes increasingly difficult. This is particularly important for processes involving shear-sensitive cells growing on microcarriers or as aggregates (spheroids and embryoid bodies). Examples include processes using induced pluripotent stem cells (iPSCs; cell therapy), mesenchymal stem cells (MSCs, cell therapy), Vero cells (vaccines), and even bovine satellite cells (cultivated meat).

    Speakers

    Join our panelists for a discussion and Q&A

    Ramon_van_Valderen   Jasmine_Ciorciari_Square  

    Ramon van Valderen  

    Phd Researcher 

    TU Delft

    		  

    Jasmine Ciorciari

    Key Account Manager

    Securecell AG

    		  

    Collaboration with:

    TUDelft_logo_descriptor_rgb-png-1

     

     

    Mohi Ahmadinia

    Mohi earned a master’s degree in computer engineering from Delft University of Technology, showcasing his expertise in the field. With his prior employment at our esteemed partner, Getinge Applikon, Mohi brings a wealth of knowledge and familiarity with our products. Since the conclusion of 2022, Mohi has held the position of Senior Marketing Manager at Securecell, contributing his valuable insights and working from our branch office located in the Netherlands.

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