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Numera® - Advanced Bioprocess Sampling Solution

Numera® is a fully automated sampling system that never sleeps, integrating and improving every process analytical technology with reliable real-time results 24/7. Combined with Lucullus® software, Numera® is a seamless all in one sampling solution.

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"Whether on- or off-line, Numera delivers accurate HPLC data fast and with little effort."
- DR. Ueli von Ah

Biotechnology Research Group Leader, Agroscope

"High-density, time-resolved data reduce the number of experiments!"
- PROF. Christoph Herwig

Professor for Biotchemical Engineering, TU Wien

"Numera improved the automation of our Continuous Countercurrent Tangential Chromatography (CCTC) System."
- Oleg Shinkazh

CEO and Founder, ChromaTan Corp.

“Securecell’s support goes beyond the simple supplier-customer relationship. With Securecell we chose a partner that is actively supporting us in our mission of automating and digitalizing our laboratory environment.”
- Nick Wierckx

Professor at Institute of Bio- and Geosciences Forschungszentrum Jülich

NUMERA®

Key Features
  • Sampling from up to 16 vessels
  • 2 to 3 ml sampling volume
  • Sampling time ~8 minutes
  • Sample storage and cooling
  • Sample transfer to up to 4 analyzers
  • Unique filtration technology for cell removal

NUMERA®

Key Benefits
  • Automated sampling 24/7
  • High frequency and low volume sampling
  • Individual sample preparation including consistent cell removal.
  • On-line measurements with common analyzers
  • Automated data import from analyzers and advanced feedback control loops with Lucullus®

  • Sterile Interface

    The Multiplexer offers 4 connections for single use sample lines, which can be connected to bioreactors or vessels. Sterility is ensured through pinch valves and ethanol. A Numera system can include up to 4 Multiplexer modules.

  • Flexible Sample Processing

    The Routing Module interconnects the various modules and offers transfer of samples to the Autosampler and up to 4 analyzers.

  • Precise Dilution

    The cell containing samples can be diluted or mixed with a reagent using a highly precise syringe drive. Dilution rate can be varied between 1:2 to 1:20.

  • Unique Membrane Filtration

    The unique loss free membrane filtration with tangential flow  enables gentle and complete cell removal with low sample volumes. Various pore sizes from 0.2 to 1.2 µm are available.

  • Sample Storage

    The Autosampler is equipped with Peltier cooling racks and can be used with various sample vials from 1.5 to 10ml. The device is available in two sizes with space for up to 384 vials.

  • HPLC Integration

    An inject valve for HPLC (up to 20’000 psi) can be included in the Autosampler setup. Direct inject provides loss free and fast analytics with HPLC system of various vendors.

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Related Articles on Numera®

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Written by: Pascal Vonlanthen / 6 min read
ADVANCED REAL-TIME MONITORING IN A CONTINUOUS BIOPROCESS
March 21, 2023

Automated sampling with Numera® as a central hub along a continuous bioprocess, enabling advanced real-time monitoring and process wide-control.

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FACILITATED AND RELIABLE PROCESS MONITORING DURING VACCINE PROCESS DEVELOPMENT AND PRODUCTION USING THE AUTOMATED SAMPLING SYSTEM NUMERA®
October 26, 2022

Vaccines are one of the most effective, cost-efficient, and sustainable ways of controlling infectious diseases and have had a significant impact on public health and longevity as well as intensive livestock production.

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AUTOMATED ON-LINE CELL CULTURE MONITORING USING NUMERA® AND THE CEDEX® HIRES ANALYZER
May 4, 2022

Every biopharmaceutical process aims for real-time monitoring and control of critical process parameters to minimize process variability and at the same time ensure predefined product quality.

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