Numera® - Advanced Bioprocess Sampling Solution
Numera® is a fully automated sampling system that never sleeps, integrating and improving every process analytical technology with reliable real-time results 24/7. Combined with Lucullus® software, Numera® is a seamless all in one sampling solution.


"Whether on- or off-line, Numera delivers accurate HPLC data fast and with little effort."
- DR. Ueli von Ah
Biotechnology Research Group Leader, Agroscope
"High-density, time-resolved data reduce the number of experiments!"
- PROF. Christoph Herwig
Professor for Biotchemical Engineering, TU Wien
"Numera improved the automation of our Continuous Countercurrent Tangential Chromatography (CCTC) System."
- Oleg Shinkazh
CEO and Founder, ChromaTan Corp.
“Securecell’s support goes beyond the simple supplier-customer relationship. With Securecell we chose a partner that is actively supporting us in our mission of automating and digitalizing our laboratory environment.”
- Nick Wierckx
Professor at Institute of Bio- and Geosciences Forschungszentrum Jülich
NUMERA®
Key Features
- Sampling from up to 16 vessels
- 2 to 3 ml sampling volume
- Sampling time ~8 minutes
- Sample storage and cooling
- Sample transfer to up to 4 analyzers
- Unique filtration technology for cell removal
NUMERA®
Key Benefits
- Automated sampling 24/7
- High frequency and low volume sampling
- Individual sample preparation including consistent cell removal.
- On-line measurements with common analyzers
- Automated data import from analyzers and advanced feedback control loops with Lucullus®
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Sterile Interface
The Multiplexer offers 4 connections for single use sample lines, which can be connected to bioreactors or vessels. Sterility is ensured through pinch valves and ethanol. A Numera system can include up to 4 Multiplexer modules.
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Flexible Sample Processing
The Routing Module interconnects the various modules and offers transfer of samples to the Autosampler and up to 4 analyzers.
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Precise Dilution
The cell containing samples can be diluted or mixed with a reagent using a highly precise syringe drive. Dilution rate can be varied between 1:2 to 1:20.
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Unique Membrane Filtration
The unique loss free membrane filtration with tangential flow enables gentle and complete cell removal with low sample volumes. Various pore sizes from 0.2 to 1.2 µm are available.
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Sample Storage
The Autosampler is equipped with Peltier cooling racks and can be used with various sample vials from 1.5 to 10ml. The device is available in two sizes with space for up to 384 vials.
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HPLC Integration
An inject valve for HPLC (up to 20’000 psi) can be included in the Autosampler setup. Direct inject provides loss free and fast analytics with HPLC system of various vendors.


Related Articles on Numera®
ADVANCED REAL-TIME MONITORING IN A CONTINUOUS BIOPROCESS
March 21, 2023Automated sampling with Numera® as a central hub along a continuous bioprocess, enabling advanced real-time monitoring and process wide-control.
FACILITATED AND RELIABLE PROCESS MONITORING DURING VACCINE PROCESS DEVELOPMENT AND PRODUCTION USING THE AUTOMATED SAMPLING SYSTEM NUMERA®
October 26, 2022Vaccines are one of the most effective, cost-efficient, and sustainable ways of controlling infectious diseases and have had a significant impact on public health and longevity as well as intensive livestock production.
AUTOMATED ON-LINE CELL CULTURE MONITORING USING NUMERA® AND THE CEDEX® HIRES ANALYZER
May 4, 2022Every biopharmaceutical process aims for real-time monitoring and control of critical process parameters to minimize process variability and at the same time ensure predefined product quality.