Introduction
Continuous perfusion processes rely on the accurate delivery of large medium volumes over extended cultivation periods. In practice, mechanical variability, backpressure effects, and limited measurement resolution often undermine rate-based feeding strategies, leading to cumulative dosing errors.
In collaboration with Safi Biotherapeutics, Securecell has developed a practical control strategy in the Lucullus® software platform that addresses these challenges by applying gravimetric corrections to the feed delivery. Rather than the instantaneous feed rate, these corrections are based on the cumulative amount of medium delivered. By regulating the integrated mass of feed over time, the strategy compensates for pump drift and measurement noise and maintains accurate overall dosing. Applied to perfusion processes at Safi Biotherapeutics, the approach enabled stable and reproducible operation under variable hydraulic conditions and common operational disturbances. The results highlight gravimetric control as a practical and robust foundation for perfusion process development in complex R&D environments.
In the webinar “Implementing Gravimetric Feed Control in Perfusion-Based Cell Culture Processes,” the gravimetric control strategy developed for Safi will be presented and its performance discussed.
Highlights of this webinar:
- Overview of key challenges in continuous perfusion cell culture
- Limitations of conventional rate-based feeding strategies in long-duration perfusion processes
- Gravimetrically corrected feed control by Lucullus®, based on cumulative mass delivery
- Performance assessment, demonstrating stable, accurate, and reproducible operation
- Q&A
This webinar meets twice; please join based on your availability.
Thu, February 19, 2026, 09:00 - 10:00 AM CET
Thu, February 19, 2026, 05:00 - 06:00 PM CET
Duration: 50 min (content) + 10 min (Q&A)
