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Bioprocess sampling: a necessary evil or a chance for improved monitoring and control?

Written by: L. Neutsch, A. Hofer, P. Kroll

 

Monitoring and control of critical process parameters (CPPs) in various bioprocesses is a prerequisite to gain a safe product and hence, is a major topic in Process Analytical Technology (PAT). The most widespread methods for process monitoring are linked to sampling. Sample-based monitoring has various advantages: direct measurement of specific analytes; usage of highly automated offline analyzers; reliability through application of reference methods; extensive parallelization; flexibility and storage of reference samples for later analysis.

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